Job Description

We are seeking a  Sr. Research Specialist who will work in a research laboratory that studies Age-Related Macular Degeneration. Studies address the role of mitochondrial dysfunction, cigarette smoke, oxidative stress on the retina and retinal pigmented epithelium in mouse models, tissue culture, and human histopathologic tissue. The candidate must be capable of exercising independent judgment while participating in the planning of experiments and evaluating and interpreting results. Uses scientific knowledge and lab experience to make judgments and decisions.

Specific Duties & Responsibilities

• Primary role will be to manage the mouse smoking chamber. Must be able to manage mice in a satellite facility and function as an animal facility specialist (all aspects of animal husbandry, ensure mice are fed, watered, and in a clean environment, suggest preventative and maintenance health plans when needed, identify animal health concerns).
• Manage the mouse colony that includes breeding genetically modified mice.
• Participate in mouse experiments and function as a veterinarian technician (follow approved protocols, maintain daily records including smoking log of cigarettes used, collect samples for analysis, make sure treatments are followed, order supples using JHU SAP system, daily report to supervisor and team)
• Will provide training to other individuals who may be assigned to the laboratory on a regular or temporary basis.
• May be assigned an independent project and participate in the creation of manuscripts.
• Work collaboratively or independently using techniques that include molecular biology assays (single cell RNA-sequencing, single cell ATAC-sequencing, proteomics, bioinformatic analysis of omics assays, real-time PCR especially for genotyping mice, RNA sequencing, Western blot analysis, ELISA, immunohistochemistry) and willingness to learn these techniques. Scientifically, special interest in mitochondrial microRNAs, non-coding RNAs, and stress granules as it relates to immunity, aging, and AMD.
• Develop protocols for PI approval, and design experimental approaches to research projects.
• May train and advise students and assist them in problem-solving and with more challenging research assays.
• Collaborate in development of new techniques and instruments.
• Responsible for laboratory inventory and ordering of supplies.
• Use universal safety precautions to protect self and co-workers from biohazardous materials. Comply with biohazard/radiation safety standards through proper handling of potentially hazardous chemical and biological agents and/or radiation sources in the workplace.
• Carry out duties and responsibilities independently.
• Make decisions and establish work priorities with minimal input from supervisor. Routine communication with laboratory colleagues and with supervisor. Will communicate with external departments such as Radiation Safety, Health, Safety and Environment, and with external vendors.

• Bachelor's Degree in Biology, Chemistry or related field.
• Four year's experience in a comparable laboratory performing relevant techniques.
• Master's degree, with related graduate research, may substitute for experience to the extent permitted by the JHU equivalency formula.

• PhD or the equivalent in cell biology, biochemistry or molecular biology. ALAT certified preferred.
• Must be able and willing to work with laboratory mice and rats. Must be familiar with tissue culture or sterile technique.
• Must be familiar with standard computer software including Word, Excel and Photoshop.

Classified Title: Sr. Research Specialist 
Role/Level/Range: ACRP/04/MC  
Starting Salary Range: $48,000 - $84,100 Annually (Commensurate with experience) 
Employee group: Full Time 
Schedule: Monday-Friday, 8:30 am - 5:00 pm 
Exempt Status: Exempt 
Location: School of Medicine Campus 
Department name: ???????SOM Oph Retina Service  
Personnel area: School of Medicine 

About Johns Hopkins University

Johns Hopkins University remains committed to its founding principle, that education for all students should be grounded in exploration and discovery. Hopkins students are challenged not just to learn but also to advance learning itself. Critical thinking, problem solving, creativity, and entrepreneurship are all encouraged and nourished in this unique educational environment. After more than 130 years, Johns Hopkins remains a world leader in both teaching and research. Faculty members and their research colleagues at the university's Applied Physics Laboratory have each year since 1979 won Johns Hopkins more federal research and development funding than any other university. The university has nine academic divisions and campuses throughout the Baltimore-Washington area. The Krieger School of Arts and Sciences, the Whiting School of Engineering, the School of Education and the Carey Business School are based at the Homewood campus in northern Baltimore. The schools of Medicine, Public Health, and Nursing share a campus in east Baltimore with The Johns Hopkins Hospital. The Peabody Institute, a leading professional school of music, is located on Mount Vernon Place in downtown Bal ... timore. The Paul H. Nitze School of Advanced International Studies is located in Washington's Dupont Circle area.

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